中文摘要：

目的观察重型颅脑损伤患者应用高容量血液滤过（HVHF）对其颅内压（ICP）及预后的影响。方法选取90例GCS评分3~8分的颅脑损伤患者按照治疗方法不同分为治疗组60例与对照组30例,对照组给予常规治疗措施,治疗组在此基础上给予HVHF,连续治疗2周后评价患者ICP变化及预后。结果治疗组3 d、7 d及14 d时颅内压均明显低于对照组（P〈0.05）,3 d、7 d及14 d时血清IL-6、TNF-α值均明显低于同期对照组（P〈0.05）,术后并发症及死亡率均明显低于对照组（P〈0.05）,具有统计学意义。结论重型颅脑损伤患者术后应用HVHF治疗可显著降低颅内压增高曲线,改善患者预后。

英文摘要：

Objective To evaluate the prognosis and influence of high-volume hemofiltration（ HVHF） on intracranial pressure（ ICP）in patients with severe traumatic brain injury. Methods A total of 90 patients with severe traumatic brain injury who had Glasgow Coma Scale scores（ GCS） of 3- 8 were divided into two groups according to different treatment approaches. The control group（ n = 30）received conventional therapy,and the treatment group（ n = 60） was treated with HVHF in addition to the conventional therapy.Change in ICP and prognosis were evaluated 2 weeks after the treatment. Results The ICP of patients in treatment group on days 3,7,and 14 of treatment was significantly lower than that in control group on respective days（ all P 0. 05）. The serum levels of interleukin-6 and tumor necrosis factor-α in treatment group on days 3,7,and 14 of treatment were significantly lower than those in control group on respective days（ all P 0. 05）. The incidence of postoperative complications and overall mortality in treatment group were significantly lower than those in control group（ both P 0. 05）. Conclusions HVHF treatment markedly slows the rise of ICP and greatly improves the prognosis in patients with severe traumatic brain injury after surgery.