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长穗桑中的苯并呋喃类化合物
  • 期刊名称：长穗桑中的苯并呋喃类化合物. 谭永霞, 刘超, 陈若芸. 药学学报, 2008, 43 (11):
  • 时间：0
  • 分类：R284.1[医药卫生—中药学;医药卫生—中医学]
  • 作者机构：[1]中国医学科学院、北京协和医学院药物研究所中草药物质基础与资源利用教育部重点实验室,北京100050
  • 相关基金：国家自然科学基金资助项目（20432030）.
  • 相关项目：高效快速新颖结构天然产物的发现及其生物活性研究
关键词： 长穗桑, 抗氧化, 苯并呋喃类化合物, Morus wittiorum, antioxidant, 2-arylbenzofuran derivatives
中文摘要：

为了研究长穗桑中具有抗氧化活性的化学成分,采用硅胶、Sephadex LH-20、RP-C18等色谱方法从长穗桑茎皮的95%乙醇提取物中分离得到7个苯并呋喃类化合物：wittifuran D（1）、wittifuran E（2）、moracin C（3）、moracin M（4）、moracin P（5）、2-（3,5-dihydroxyphenyl）-5,6-dihydroxybenzofuran（6）和mulberroside C（7）,并通过NMR、MS等波谱分析手段鉴定了化合物的结构。化合物1~7均为首次从该种植物中分离得到,其中化合物1和2为新化合物。对化合物3~7进行了抗氧化活性筛选,其中化合物3、4、6浓度在1×10-5mol.L-1时对Fe2＋-半胱氨酸诱导的肝微粒体脂质过氧化产生的丙二醛（malondialdehyde,MDA）的抑制率分别为73%、69%和89%。

英文摘要：

The investigation on the stem bark of Morus wittiorum was carried out to find its chemical constituents possessing anti-oxidative activity. The isolation and purification were performed by various chromatographies such as silica gel, Sephadex LH-20, RP-C18 column chromatography and so on. Based on the spectral analysis such as NMR, MS, etc. , seven 2-arylbenzofuran derivatives were identified as wittifuranD （1）, wittifuran E （2）, moracin C （3）, moracin M （4）, moracin P （5）, 2-（3,5- dihydroxyphenyl） -5,6-dihydroxybenzofuran （6） and mulberroside C （7）. Compounds 1 - 7 were isolated from this plant for the first time. Among them, 1 and 2 were new compounds. Compounds 3 -7 were used to assay antioxidant activity, the inhibitory ratios of compounds 3, 4, 6, at a concentration of 1×10^-5 mol· L^- 1, to malondialdehyde （MDA） produced during microsomal lipid peroxidation induced by ferrouscysteine were 73%, 69% and 89% respectively.

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高效快速新颖结构天然产物的发现及其生物活性研究
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