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Star-shaped Conjugated Oligoelectrolyte for Bioimaging in Living Cells

期刊名称：Chinese Science Bulletin
时间：2013
页码：2570-2575
分类：TB873[一般工业技术—摄影技术] TH742[机械工程—光学工程;机械工程—仪器科学与技术;机械工程—精密仪器及机械]
作者机构：[1]Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications (NJUPT), Nanjing 210046, China
相关基金：This work was supported by the National Basic Research Program of China （2009CB930600, 2012CB933301 and 2012CB723402）, the Ministry of Education of China （IRT1148）, the National Natural Science Foundation of China （21222404, 51173080 and 21104033）, the Program for New Century Excellent Talents in University （NCET-10-0179）, the Specialized Research Fund for the Doctoral Program of Higher Education （20093223110003）, the Natural Science Foundation of Jiangsu Province of China （BZ2010043 and NY211003）, and the Program for PostgraduatesResearch Innovation of Colleges and Universities of Jiangsu Province （ CXLX 11_04 2 4 and CXLX 11_ 0424_0414）
相关项目：光电功能高分子/纳米生物传感

关键词：活细胞成像, 生物成像, 共轭, 星形, 超支化聚合物, 直接成像, 平均直径, 纳米微球, star-shaped, oligoelectrolyte, absolute quantum yield, nanospheres, bioimaging

中文摘要：

有是的 triphenylamine 的新塑造星的 oligoelectrolyte (TEFCOONa ) 核心，乙炔作为是的连接和 anionic fluorenes，手臂被获得并且在生活 PANC-1 房间为直接成像使用了。因为 oligoelectrolyte 的恐水病的结合的组， TEFCOONa 能在 10 mmol/L PBS 与 75 nm 的一条平均直径形成 nanospheres。这些 nanospheres 拥有相对高的绝对的量收益(16.5% 在 PBS ) ，低 cytotoxicity 和罐头通过细胞质渗透进原子核，它为生活是必要的细胞的成像。一起，这些结果为 bioimaging 和另外的临床的应用作为有效 nanovectors 验证我们结合的 oligoelectrolyte 和甚至亢奋的分叉的 polymers-copolyelectrolyte 的合理设计。

英文摘要：

A new star-shaped oligoelectrolyte （TEFCOONa） with triphenylamine as the core, acetylene as linkage and anionic fluorenes as arms was obtained and used for direct imaging in living PANC-1 cells. Because of the hydrophobic conjugated groups of the oli- goelectrolyte, TEFCOONa can form nanospheres with an average diameter of -75 nm in 10 mmol/L PBS. These nanospheres possess a relatively high absolute quantum yield （16.5% in PBS）, low cytotoxicity and can penetrate into the nucleus through the cytoplasm, which is essential for living cellular imaging. Collectively, these results validate our rational design of conjugated oligoelectrolyte and even hyper branched polymers-copolyelectrolyte as effective nanovectors for bioimaging and other clinical applications.

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