中文摘要：

微管微丝交联因子1（microtubule actin cross-linking factor 1,MACF1）是一种新的细胞骨架交联蛋白,属于血影斑蛋白（spectraplakin）家族成员之一,包含3个基本结构域即N末端结构域、杆状结构域及C末端结构域。其主要功能是交联微丝微管细胞骨架,参与细胞信号转导、蛋白质运输、胚胎发育以及疾病发生等过程。近年来,MACF1在细胞骨架动力学过程中的作用备受关注。现就该分子的结构与功能的最新研究进展进行综述。

英文摘要：

Microtubule actin cross-linking factor 1 （MACF1） is a novel cytoskeletal linker protein and belongs to spectraplakin family. Structurally, MACF1 contains 3 domains, namely an N-terminal domain, a rod domain and a C-terminal domain. MACF1 takes an important role in associating with both actin microfilaments and microtubules and participating in signal transduction, protein transportation, embryonic development and disease occurrence. Recently the roles of MACF1 in regulating microtubule-actin dynamics have been paid much more attention. This review focuses on the latest research progress of the structure and functions of MACF1.