中文摘要：

目的探讨针刺干预对Y123F雄性肥胖小鼠的体重、糖脂代谢及肝脏的影响。方法将11只小鼠随机分为两组,实验组6只,对照组5只,实验组选取中脘和双侧后三里穴进行13 d的针刺干预,对照组与实验组以同样的方式固定,但不针刺。结果实验组小鼠的体重、血糖、血清瘦素水平与对照组比较,均有显著性差异（P〈0.05）;而高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、甘油三酯（TG）以及总胆固醇（TC）水平与对照组比较,则无统计学差异（P〉0.05）。结论针刺干预能够有效改善Y123F雄性小鼠的肥胖程度、高血糖、血清高瘦素水平,并改善肝脏质量,但对小鼠脂代谢并无明显改善。

英文摘要：

Objective To investigate the effect of acupuncture intervention on body weight, glycolipid metabolism and the liver in male obese Y123 F mice. Method Eleven mice were randomized into two groups, an experiment group of 6 mice and a control group of 5 mice. In the experiment group, point Zhongwan（CV12） and bilateral points Housanli（ST36） were given 13 days of acupuncture intervention. In the control group, mice were fastened in the same way as in the experiment group but not given acupuncture. Result There were statistically significant differences in body weight, and blood sugar and serum leptin levels（P〈0.05） but no statistically significant differences in high density lipoprotein（HDL-C）, low density lipoprotein（LDL-C） and triglyceride（TG）（P〉0.05） between the experiment and control groups. Conclusion Acupuncture intervention can effectively reduce the degree of obesity and high blood sugar and serum leptin levels and improve liver quality but not markedly ameliorate lipid metabolism in male Y123 F mice.