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中文摘要：
线粒体融合蛋白2（mitofusin-2,Mfn2）是一种高度保守的跨膜GTP酶,在线粒体融合中的关键作用已为人所熟知.随着认识的不断深入,Mfn2在介导线粒体融合之外的功能日渐显现,其在细胞信号转导、能量代谢、增殖及凋亡等生命过程中均具有重要调节作用.Mfn2效应的广泛性及作用机制的复杂性预示着其在现代生物医学中可能极具应用价值.综述了Mfn2结构和生物学功能研究的最新认识,并简要介绍了Mfn2功能或表达异常与疾病发生的关系及其治疗学意义.
英文摘要：
Mitofusin-2 （Mfn2） is a highly conserved transmembrane GTPase which plays a critical role in mitochondrial fusion process. Recent data have been demonstrated that Mfn2 is involved in the regulation of several crucial cellular pathways beyond fusion, including mitochondrial metabolism, cellular signaling cascade, apoptosis and proliferation. With multiple functions and complex mechanisms, Mfn2 might play potential role in the applications in modern medicine. The structure and basic biological function of Mfn2 were summarized, furthermore, the dysfunction of Mfn2 in certain diseases and its therapeutic value were also discussed.
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