中文摘要：

移植肾早期不可避免地存在缺血再灌注损伤（IRI），对移植。肾的早期恢复和远期预后均有重要影响。缺血-再灌注除损伤肾小管上皮细胞外，还导致间质炎症和微血管病变；而后者是IRI引起肾功能障碍的关键。缺血后微血管病变以内皮细胞肿胀和随之而来的微血管闭塞为特征，导致再灌注不能顺利进行（无复流现象）。阐明内皮细胞功能障碍机制，为移植肾IRI的治疗提供新思路。

英文摘要：

Ischemia-reperfusion injury （IRI） has been an inevitable event accompanying kidney transplantation. It has a profound influence on both the early and the late function of a transplanted kidney. Ischemia-reperfusion does not exclusively lead to alterations of epithelial cells but also causes interstitial inflammation and interstitial microvaseulopathy. Both inflammation and microvasculopathy are particularly important in terms of post-ischemic kidney repair. Post-ischemic microvasculopathy is characterized by endothelial cell swelling with subsequent microvascular occlusion. Thus, reperfusion is inhibited （ no-reflow phenomenon）. Such endothelial cell dysfunction offers new therapeutic perspectives in IRI in renal transplantation.