中文摘要：

目的：探讨前列腺组织蛋白结合免疫佐剂法诱导的SD大鼠非细菌性前列腺炎的炎症反应与内环境因素之间的关系。方法：30只大鼠随机分成3组,其中一组为阴性对照组,其它两组为试验组,第0、7天多点皮内注射浓度分别为20、40mg/mL的大鼠前列腺蛋白提纯液联合完全弗氏佐剂（1∶1的混悬液）1.0mL,腹腔注射百白破疫苗0.5mL,第21天皮内注射大鼠前列腺蛋白提纯液0.5mL,阴性对照组在相同时间和部位注射同等剂量的生理盐水,造模后第55天处死大鼠。结果：前列腺蛋白提纯液联合完全弗氏佐剂制作诱导SD大鼠前列腺炎后,可见前列腺间质有大量炎细胞浸润,以淋巴细胞为主,呈现明显的慢性炎症表现。免疫因素引起的慢性非细菌性前列腺炎可导致免疫球蛋白G（IgG）浓度明显升高（P〈0.05）,免疫球蛋白M（IgM）浓度明显降低（P〈0.05）,C-反应蛋白（CRP）和前列腺特异抗原（PSA）含量明显增加（P〈0.05）。结论：根据本实验的结果,免疫性非细菌性前列腺炎大鼠体内IgG、IgM、CRP和PSA含量呈现关联性变化。

英文摘要：

AIM： To explore the internal environment correlation prostate antigen protein induced SD male rats with chronic prostatitis. METHODS： 30 male rats were randomly divided into 3 groups, each one contained 10 ones. One was negative control group; the other two groups were the experimental group. 20, 40 mg/mL of rat prostate protein purification liquid combined with complete freund＇s adjuvant （1 ： 1 mixed suspension） were injected respectively in SD rats by multipoint intradermal injection at 0, 7 days and 0. 5 mL of DPT vaccine was injected by intraperitoneal injection. At 21 days, 0.5 mL 20, 40 mg/mL of rat prostate protein purification liquid combined with complete freund＇s adjuvant were injected respectively in SD rats by intradermal injection. The negative control group was injected by equal dose of normal saline at the same time and place. RESULTS： Histopathological analyses indicated that there was inflamma- tory infiltrates in the experimental groups prostate stromal, which showed obvious chronic inflammation. Immune factors of chronic nonbacterial prostatitis can lead to IgG concentration increased significantly （P 〈 0.05）, CRP and PSA levels increased significantly （P 〈 0.05 ）. CONCLUSION： According to the experimental results, chronic non-bacterial prostatitis induced by prostate antigen protein lead to IgG concentration, CRP and PSA levels increased significantly.