中文摘要：

固体脂质纳米粒（SLN）是20世纪90年代发展起来的一种性能优异的新型纳米粒给药剂型作为一种新型载体,可有效提高包封药物的稳定性、提高病变部位靶向性、低毒性与组织亲和性,为药物的体内递送提供了一种新的方法。本文主要针对固体脂质纳米粒的制备,发展现状,目前存在的问题及解决思路等作以介绍与总结。并在此基础上,介绍了新的脂质纳米粒,纳米脂质载体（nanostructured lipid carriers,NLC）和药脂结合物纳米粒（Lipid drug conjugate nanoparticles,LDC）,以及未来固体脂质纳米粒的发展方向。

英文摘要：

Solid lipid nanoparticles（SLN） is an excellent new nanoparticles drug delivery system which developed rapidly since1990 s. As a new vector, solid lipid nanoparticles may improve the stability of the encapsulated drugs, enhance targeting efficiency to the diseased site, low toxicity and biocompatibility. It has provided a promising method for drug delivery. This paper reviewed the preparation, development, the problems and solution in its application of the SLN nano-carriers. Based on previous study, nanostructured lipid carriers（NLC） and lipid drug conjugated nanoparticles（LDC） and the development of the solid lipid nanoparticles were also introduced in this artcle.