螺环氧化吲哚结构是很多药理活性分子的核心骨架,其结构复杂且在合成过程中立体选择性难以控制,因此含有该骨架的化合物是药物和有机化学家关注的热点。按吲哚C(3)位上构建的三元螺环、四元螺环、五元螺环和六元螺环进行分类,介绍近5年来有机小分子不对称催化构建螺环氧化吲哚化合物的研究进展,以期为该类化合物的合成提供参考价值。
The spirooxindole skeletons have captured tremendous attention among synthetic and medicinal chemists,due to the prevalence pharmacological activities,complex structures and stereoselectivity. This work reviews the progress of the organocatalytic construction of chiral spirooxindoles in recent five years,primarily classified according to the three-membered spiro ring,fourmembered spiro ring,five-membered spiro ring and six-membered spiro ring compounds fused at the C(3)-position of oxindole core,which provide valuable information for the synthesis of these compounds.