中文摘要：

胃肠道黏膜有两个黏蛋白层,内层紧密而外层疏松,这两层都由大量黏蛋白（MUC2）组成。小肠病原菌通过自身运动性、黏液溶解活性和其他有害因子的毒性,削弱黏液层的保护功能,致使黏液层变薄和通透性增加,从而接触并入侵上皮细胞。黏液层在建立共生肠道菌群、防御致病微生物的移植和入侵上扮演着重要的角色。

英文摘要：

There are two mucus gel layers in the gastrointestinal mucosa,an inner firmly adherent layer and an outer more loosely adherent layer,both consisting largely of MUC2 mucin in the intestine of mucins.Small intestinal pathogens weaken the mucus layer protectionthrough their own exercise,mucolytic activity and other harmful factors of toxicity,resulting in thinning of the mucous layer and permeability,and thus contact and invasion of epithelial cells.The mucus layers play key roles in the establishment of the commensal intestinal microbiota and the protection from colonization and invasion by the pathogenic microbiota.