结构和基因的基础作文怎么随着脊椎动物的进化变化了,仍然是一个思索的问题。这里,我们分析了 895 orthologous 在六个多细胞的动物的编码蛋白质的基因:人,鸡肉, zebrafish,海喷射,水果苍蝇,和蠕虫。我们的分析表明许多基因区域,特别地 intron 和 3 UTR,逐渐地从他们的无脊椎的祖先在整个脊椎动物的进化膨胀了,并且 exons 的数字每基因增加了。研究基于在每个染色体的所有编码蛋白质的基因提供一致结果。我们也发现那个 GC 内容在温血动物的进化在许多基因区域(特别 5 UTR ) 增加了,除了在 coding-exons。单个染色体的分析比有在所有六种的大 intron 的 5 UTR,和基因表明相对类似的 GC 内容的证明 3 UTR 表明了有 intron 的更强壮的长度和 GC 内容关联。我们的数据在基因和我们建议的脊椎动物在复杂性显示大增加为词法、功能的变化的要求可能在多细胞的动物基因是在结构和基础作文复杂性的进化后面的驱动力。
How the structure and base composition of genes changed with the evolution of vertebrates remains a puzzling question. Here we analyzed 895 orthologous protein-coding genes in six multicellular animals: human, chicken, zebrafish, sea squirt, fruit fly, and worm. Our analyses reveal that many gene regions, particularly intron and 3~ UTR, gradually expanded throughout the evolution of vertebrates from their invertebrate ancestors, and that the number of exons per gene increased. Studies based on all protein-coding genes in each genome provide consistent results. We also find that GC-content increased in many gene regions (especially 5' UTR) in the evolution of endotherms, except in coding-exons. Analysis of individual genomes shows that 3t UTR demonstrated stronger length and GC-content correlation with intron than 5~ UTR, and gene with large intron in all six species demonstrated relatively similar GC-content. Our data indicates a great increase in complexity in vertebrate genes and we propose that the requirement for morphological and functional changes is probably the driving force behind the evolution of structure and base composition complexity in multicellular animal genes.