中文摘要：

雌激素受体α（estrogen responsec α，ERα）通过调控多种靶基因的转录来发挥其重要的生物学功能，这一过程依赖于共调节因子的调控。肿瘤转移相关蛋白（metastasis—associated protein，MTA）是近年来受到广泛重视的ERα共抑制因子，其家族成员分别是不同的核小体重构和组蛋白脱乙酰基酶（nucleosomere modeling and histone deacetylase，NuRD）复合体的亚基，在ERa的信号通路中发挥着不同的作用，与乳腺癌、肝癌、卵巢癌等的发生、发展有密切联系。MTA1既可抑制又可刺激ERct的转录；MTA2能够对ERa的转录活性产生抑制作用；而MTA3的表达受ERa的调节。主要就MTA1、2、3在ERa信号通路中的作用以及它们对肿瘤发生转移过程的影响作一综述。

英文摘要：

Estrogen receptor α （ERα） relies on coregulators （coactivators and corepressors） to modulate the transcription of various target genes. Metastasis-associated proteins （MTA） are an emerging family of ERα corepressor, which form independent parts of nucleosome remodeling and histone deacetylase （NuRD） complexes and are involved in the progression of breast cancer, hepatocellular carcinoma, oophoroma and so on. MTA1 can not only repress but also stimulate the ERα transcription, whereas MTA2 can only repress the transactivation of ERα. However, the expression of MTA3 is regulated by ERα. Here we summed up the roles of the MTA1, 2, and 3 in ERα signaling and cancer progression.