中文摘要：

采用模板聚合法以甲基丙烯酸（MA）、甲基丙烯酰氧乙基磷酰胆碱（MPC）为单体，以过硫酸钾为引发剂和壳聚糖进行聚合，制备具有仿细胞外层膜结构壳聚糖纳米颗粒。用动态光散射仪（DLS）、透射电镜（TEM）和zeta电位对纳米颗粒的粒径、zeta电位进行表征，并通过体外阿霉素控释实验对该纳米颗粒的控释性能进行研究。该仿细胞外层膜结构壳聚糖纳米颗粒将在基因治疗、药物控释等领域具有巨大的应用前景。该研究对于探索仿细胞外层膜结构纳米颗粒的控释性能具有重要的学术意义。

英文摘要：

The cell outer membrane mimetic structures of nanoparticles were prepared using methacrylic acid （MA）, 2-methacryloyloxyethyl phosphorylcholine （MPC） as monomer, potassium persulfate （KPS） and chi- tosan by template polymerization. The size distribution and structure properties of nanoparticles were character- ized by transmission electron microscopy （TEM）, dynamic light scattering （DLS） and zeta potential. The drug release properties of nanoparticles were estimated by doxorubicin in vitro release experiment. The cell outer membrane mimetic structures of nanoparticles might have potential applications in the fields of gene therapy and drug delivery. The controlled release properties had been an important academic significance on the study of outer cell membrane structures of nanoparticles.