中文摘要：

目的 探讨血清中蛋白聚糖-1（syndecan-1）的水平与糖尿病微血管病变的相关性. 方法 选取糖尿病患者55例,其中单纯糖尿病者（DM组）27例,合并糖尿病视网膜病变者（DR组）8例,合并糖尿病慢性肾脏疾病者（CKD组）8例,同时合并DR和CKD者（DR＋ CKD组）12例.另选取健康对照者（NC）9名.采用酶链免疫吸附试验检测血清中syndecan-1的水平,并分析syndecan-1与DR和CKD的相关性. 结果 DM、DR、CKD、DR＋CKD及NC组血清中syndecan-1的浓度分别为（26.79±16.89）、（18.83±8.74）、（69.44±52.58）、（80.33±94.28）及（21.59±14.50） ng/ml,各组间比较差异有统计学意义（x2=13.5600,P=0.0088）.CKD、DR＋ CKD组与NC组比较,差异有统计学意义（x2=4.8000、7.3400,P=0.0284、0.0067）.方差分析结果表明,CKD是决定血清syndecan-1浓度的因素（F=4.9600,P=0.0313）.多元线性回归分析结果表明,血肌酐（Scr）水平对血清syndecan-1浓度有极大的决定作用（R2=0.8000）. 结论 CKD患者血清syndecan-1水平明显升高,Scr水平与糖尿病患者血清syndecan1的水平明显相关.

英文摘要：

Objective To study the correlation of serum syndecan-1 with diabetic microangiopathy.Methods Serum syndecan-1 was detected by enzyme-linked immunosorbent assay.Association of serum syndecan-1 with diabetic retinopathy and diabetic neuropathy was determined by statistical analysis.Results Fifty-five individuals with diabetes （27 without any diabetic complication,8 with diabetic retinopathy,8 with diabetic nephropathy,12 with diabetic retinopathy plus diabetic neuropathy）and 9 healthy age-matched subjects（control group）were enrolled.Serum syndecan-1 was （21.59± 14.50） ng/ml in the group of controls,（26.79 ± 16.89） ng/ml in diabetes without any diabetic complication,（18.83 ± 8.74） ng/ml in diabetic retinopathy,（69.44±52.58） ng/ml in diabetic neuropathy,and （80.33±94.28） ng/ml in diabetic retinopathy plus diabetic neuropathy with differences being significant among 5 groups （x2 =13.5600,P =0.0088）.The difference in serum syndecan-1 was significant（x2 =4.8000,P =0.0284） between diabetic neuropathy group and control group; and significant（x2 =7.3400,P=0.0067） between control group and group with diabetic retinopathy and diabetic neuropathy,Diabetic neuropathy was one important determined factor for the levels of serum syndecan-1（ANOVA,F=4.9600,P=0.0313）.We set syndecan-1 as the outcome variable and renal function（urea nitrogen and creatinine）as the independent variables,and multiple linear regression analysis was done.It showed that serum creatinine levels determined greatly on serum syndecan-1 level（R2=0.8000）.Conclusion In patients with diabetes,serum syndecan-1 is associated with diabetic nephropathy.Serum creatinine level is correlated with the levels of serum syndecan-1 in diabetes.