目的研究在烧伤及药理学实验中计算C57BL/6小鼠全身体表面积(BSA)时Meeh常数(k)的取值。方法测量20只C57BL/6小鼠的体重和BSA,并计算出小鼠的实际k值,比较其与5个正常小鼠常用k值(6.0、9.1、9.5、10.0和11.4)间的差异。结果小鼠BSA计算所得的k值为9.715±0.142,与正常小鼠常用k值比较差异均有统计学意义(P〈0.01)。结论应用Meeh公式计算C57BL/6小鼠的BSA时,k值宜选用9.715。
Objective To investigate the proper Meeh constant(k) for calculating the body surface area(BSA) of C57BL/6 mouse in the experiments of burn and pharmacology study.MethodsThe body weight and BSA of twenty C57BL/6 mice were measured.The k value of each mouse was calculated and compared with the five common k values (6.0,9.1,9.5,10.0 and 11.4) in normal mice.Results The calculated k value in this group was 9.715±0.142,which was significantly different from the five frequently-used k values(P0.01).Conclusion A k value of 9.715 should be taken for calculating the BSA of C57BL/6 mouse.