目的:优选雄黄水飞炮制方法的最佳工艺条件。方法:以加水量、操作次数和干燥温度为因素水平,用L9(3)^4正交设计对炮制条件进行优选。采用离子交换高效液相色谱-氢化物发生-原子荧光光度法测定雄黄中可溶性砷盐As(Ⅲ)的含量。结果:雄黄水飞的最佳炮制工艺为加15倍量水、操作8次、干燥温度40℃。结论:此法准确、可靠,为雄黄炮制品的制备工艺和质量评价提供了一定的科学依据。
Objective: To optimize the water processing (shui-fei)condition of Realgar. Methods: The processing conditions were optimized by L9 ( 3 ) 4 orthogonal design with three factors as water dose, process times and dryness temperature. The content of dissolved arsenic As( Ⅲ ) in Realgar was tested by High Performance Liquid Chromatography-hydride generation on-line coupled with atomic fluo- rescence spectrometry(HPLC-HG-AFS). Results :The optimized conditions were 15 times quantity of water, 8 times for processing and dryness temperature of 40℃. Conclusion :The method is accurate and effective ,which can be used to evaluate the quality of processed products of Realgar.