中文摘要：

FoxO是一类重要自噬调控因子，其活性主要受SIRT1的去乙酰化调节。SIRT1-FoxO-自噬通路可能为糖尿病、衰老、肥胖、肿瘤、心血管疾病、肌肉萎缩等多种疾病提供新的防治策略。该文旨在分析 FoxO 的转录调节机制，综述SIRT1-FoxO-自噬通路的研究进展。

英文摘要：

FoxO as an important transcription factors,can be deacetylated by SIRT1 （a sort of deacetylases）,SIRT1-FoxO-au-tophagy pathway is likely to play a vital role in some diseases,e. g.diabetes,aging,obesity,cancer,cardiovascular diseases and muscle atrophy,etcetera.This paper aims to analy transcription-al regulation mechanism of FoxO,and reviews the progress of SIRT1-FoxO-autophagy pathway.