中文摘要：

目的探讨膜联蛋白A5（ANXA5）基因内含子2单核苷酸多态性（SNP）位点rs2306413与中国汉族人群不明原因性复发性流产（URSA）之间的关系。方法采用病例-对照研究的方法,对213例URSA患者和170例健康对照者ANXA5基因内含子2区域的SNP位点rs2306413进行等位基因频率和基因型分布分析。数据检验方法采用Pearson χ～2检验。结果 rs2306413的等位基因在病例组和对照组中的分布差异有统计学意义（P=0.006）;rs2306413在病例组和对照组中的基因型分布差异有统计学意义（P=0.005）;携带GG纯合基因型的患者患URSA的风险增加（OR=3.039,95%CI：1.499～6.159）。结论 ANXA5的单核苷酸多态性rs2306413可能是中国汉族人群中URSA发生的一个危险因素。

英文摘要：

Objective To investigate the association between SNP rs2306413 and URSA in the Han Chinese popu- lation. Methods A total of 213 Han Chinese women with URSA and 170 fertile healthy controls were recruited in this case-control study. Allele frequency and genotype distribution of URSA patients and controls were determined. The Pearson chi-square test was used for analysis. Results rs2306413 showed a significant association with URSA cases compared with the controls（P =0. 006）. Genotype distribution of rs2306413 in the case group and the con- trol group was statistically different （ P = 0. 005 ） . The GG genotype increased the risk for URSA （ OR = 3. 039, 95% CI：1. 499 -6. 159）. Conclusion rs2306413 may be a risk factor for URSA in the Han Chinese population.