中文摘要：

选用乳化-溶剂挥发法制备乙基纤维素载药微球（EMs），并通过内部凝胶化法进行包衣制得海藻酸钠．乙基纤维素载药微囊（AEMs），最后通过离子交联法进一步包衣制得壳聚糖-海藻酸钠-乙基纤维素载药微囊（CAEMs）．研究克拉霉素漂浮-生物粘附微囊的制备工艺，并考察微囊的体外漂浮性能、粘附性能及体内滞留性能．结果表明，CAEMs球形度较好，药物包封率为72．3％-78．2％，载药量为7．1％．12．7％．在pH：5的醋酸缓冲液中，6h时的累积释放率为56．6％-70．6％，漂浮率大于70％，4h时的体内滞留率为60.5％．CAEMs有望通过延长药物胃内滞留时间，在临床用于根除幽门螺旋杆菌，从而降低消化道溃疡的复发率．

英文摘要：

Floating-bioadhesive microcapsules containing clarithromycin were prepared by a combined method of emulsion solvent diffusion and internal/ion gelation for the treatment of Helicobacter pylori. Ethylcellulose microsphers（EMs） were prepared by the emulsion solvent diffusion method. EMs were coated with alginate and chitosan by the internal/ion gelation method to get alginate-ethylcellulose microcapsules（AEMs） and chitosan-alginate-ethylcellulose microcapsules（CAEMs）. The drug efficiency and drug content of clarithromycin in CAEMs were determined to be 72. 3%-78.2% and 7.1%-12. 7%, respectively. CAEMs showed an obviously sustaining effect for more than 6 h in vitro, and more than 70% of CAEMs floated in acetate buffer solution for 8 h in vitro. Furthermore, the in vitro remaining percentage of CAEMs in the stomach 4 h after the administration was 60. 5%. The results suggest that floating-bioadhesive microcapsules might be a promising drug delivery system for the treatment of Helicobacter pylori infection.