中文摘要：

采用斑马鱼胚胎技术和毒性1：1配比及不同毒性配比的方法，对环境雌激素类物质五氯酚（PCP）和双酚A（BPA）进行联合毒性测试结果表明，PCP和BPA在0hpf染毒且毒性效应配比1：1时，24h死亡表现为协同作用，72h孵化抑制率表现为相加作用，PCP和BPA不同毒性效应配比时，6hpf染毒的24h血流障碍有拮抗作用存在，而0hpf染毒的32h囊肿表现有协同作用存在。并且，6hpf的联合作用与0hpf联合作用相比，24h血流障碍、32h血流障碍和32h囊肿这3种毒性效应都有所降低。

英文摘要：

The joint toxicity test of environmental estrogen material of Pentachlorophenol and bisphenol A were made adopting zebrafish embryos technique and the methods of 1：1 toxicity ratio and different toxicity ratios. At zero contamination and the toxicity effect ratio of 1：1, the 24h death of PCP and BPA showed synergistic action; and additive action at 72h hatch prohibitive rate. At the joint toxicities of PCP and BPA toxicity effect rates antagonistic action existed at 24h blood balk to the 6hpf contamination; while synergistic action existed at 32h cyst of 0hpf contamination embryos. Besides, 6hpf joint action compared with that of 0hpf, the 3 kinds of toxicity effect of 24h blood balk, 32h blood balk and 32h cyst all lowered somewhat.