中文摘要：

在西藏的高血压的发生在所有中国省之中最高评价的目的。这可能由于西藏的唯一的自然环境和耕地生活方式引起的基因变化，推动我们到调查了在基因多型性和高血压之间的关系。方法血样品从 229 个高血压的参加者被收集并且 372 健康(控制) 从五个西藏的县的参加者。十七单个核苷酸多型性为他们的连接被调查到高血压。在 NOS3 基因的 rs2070744 的 C 等位基因被显示出显著地与高血压被联系的结果(P=0.0443；OR=1.636 ) 。另外， ADD 基因的 rs4961 的 T 等位基因在女人与高血压被相关(P=0.03124；OR=1.584 ) 。在我们发现了的这研究的结论 NOS3 并且补充说基因与在 Tibetans 之中的高血压的高发生有关。NOS3 基因在调整脉管的音调和血容器直径起一个作用，它可以被西藏的低氧的环境改变。增加涉及水和盐新陈代谢，它与 Tibetans 的高盐的食谱一致。关联由我们的学习阐明了与另外的种族组的那些不同，显示这些调查结果可能对西藏的人特定。

英文摘要：

Abstract Objective The incidence of hypertension in Tibet ranks highest among all Chinese provinces. This may be due to genetic changes caused by Tibet＇s unique natural environment and agrarian lifestyle, prompting us to investigated the relationship between gene polymorphisms and hypertension. Methods Blood samples were collected from 229 hypertensive participants and 372 healthy （control） participants from five Tibetan counties. Seventeen single nucleotide polymorphisms were investigated for their connection to hypertension. Results The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension （P=0.0443; OR=1.636）. Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women （P=0.03124; OR=1.584）. Conclusion In this study we found that the NOS3 and ADD genes were related to a high incidence of hypertension among Tibetans. N053 gene plays a role in regulating vascular tone and blood vessel diameter, which may be altered by the low-oxygen environment of Tibet. ADD is involved in water and salt metabolism, which is consistent with the high-salt diet of Tibetans. The correlations elucidated by our study were different from those of other ethnic groups, indicating that these findings may be specific to the Tibetan people.