中文摘要：

目的探讨Ezrin蛋白在肺腺癌组织中的表达及意义。方法应用免疫组织化学染色检测92例肺腺癌及癌旁正常组织中的Ezrin蛋白表达，结合临床病理学指标及生存时间进行统计学分析。结果肺腺癌组织中的Ezrin阳性表达率明显低于癌旁正常组织（P〈0．01），Ezrin蛋白在组织分化程度较低、有转移以及高分期的肺腺癌组织中的阳性表达率明显降低（P值分别为0．023、0．003和0．001）；癌组织中的Ezrin蛋白表达与患者的生存时间明显相关（Logrank=35．106，P〈0．01）；Ezrin阴性表达是影响患者生存时间的独立风险因子（HR：0．408，95％CI：0．232-0．717，P=0．002）。结论Ezrin基因可以影响肿瘤的发生和发展，检测肺腺癌组织中Ezrin蛋白的表达对其预后评估有一定的价值，有望成为肺腺癌靶向治疗的分子靶点。

英文摘要：

[Objective] To explore the role of Ezrin in tumor progression and prognostic evaluation oflung adenocarcinoma. [Methods] Immunohistochemistry for Ezrin protein was done to investigated the signifi-cance of Ezrin protein expression in 92 cases of lung adenocarcinoma. Additionally, the correlation betweenEzrin non-expression and the clinicopathological features of lung adenocarcinoma was evaluated by χ2 test andFisher＇s exact test, the overall survival rates were calculated by the Kaplan-Meier method, and the relation-ship between prognostic factors and patient over survival was also analyzed by the Cox analysis. [Results]Ezrin protein non-expression rate in lung adenocarcinoma was significant lower than the index in the adjacentlung tissues （P〈0.01）. Ezrin non-expression rate was correlated with the differentiation, metastasis, and patho-logic stage （P =0.023, 0.003, and 0.001, respectively）. Importantly, there was significant difference betweenEzrin non-expression rate and the overall survival rate （Log-rank= 35.106, P〈0.01）. Further analysis by Coxproportional hazard regression model, Ezrin non-expression emerged as a significantly independent hazard factor for over survival of lung adenocarcinoma （HR： 0.408, 95%CI： 0.232 - 0.717, P=0.002）. [Conclusion]Ezrin may affect the occurrence and development of lung adenocarcinoma. It might be a new attractivebiomarker for prognostic evaluation and molecular target therapy in patients with lung adenocarcinoma.