质谱分析是蛋白质组学的一项支撑技术。质谱数据处理过程具有多策略、多处理步骤、多种处理软件的特点,数据处理过程中数据格式不统一的问题给数据交换和整合带来了一定的困难,也给质谱分析平台和质谱数据库的建设带来了挑战。研究质谱数据分析中的质谱数据标准,不仅可以系统地梳理归纳目前分析方法中需要使用的全部数据信息,而且有利于质谱数据分析平台的建设。本文介绍了近几年制定的一些质谱数据标准,总结这些标准各自的特点、不足及应用情况,并展望质谱数据标准可能的发展方向。
Mass spectrometry(MS) is currently the most commonly used technology for the identification of proteins.In MS data processing,multiple strategies are frequently used to analyze MS data,and the data analysis pipeline is always divided into multiple subtasks with support of multiple software tools in each subtask.One problem of MS data processing is the non-uniform data format,which may affect MS data exchange and integration.It may lead to some challenges in the development of MS data processing platform(MSDPP) and the construction of MS databases.Studying on MS data format standards can not only provide a way to summarize information needed in MS data processing methods,but also be beneficial to the development of MSDPP.In this manuscript,some MS data format standards developed in recent years are introduced.Then,the advantage and disadvantage of each standard are summarized as well as its application,and some possible improvements of MS data format standards are proposed.