中文摘要：

奎宁和手性氨基醇通过硫脲片段组合，合成了4个新型的具有多氢键供体的双功能手性硫脲类小分子催化剂（5a～5d），其结构经1HNMR，13CNMR，IR和HR-MS表征。以查尔酮为底物，硝基甲烷为亲核试剂，考察了5a-5d在Michael加成反应中的催化活性和对映选择性。结果表明，以Na2CO3为碱，三氯甲烷为溶剂，5c为催化剂，于室温反应24h，加成产物4-硝基-1，3-二苯基丁烷-1-酮的收率69％，对映选择性86％。

英文摘要：

Four new chiral thiourea bifunctional organocatalysts（5a - 5d） were synthesized by the re- action of quinine with chiral β-amino alcohol. The structures were characterized by I H NMR, 13C NMR, IR and HR-MS. The catalytic performance and selectivity of 5a - 5d were investigated by the Michael addition between chalcone and nitromethane. The results showed that the yield was 69% with 86%e. e. of 4-nitro-1,3-diphenylbutan-1-one） （addition product） using Na2CO3 as the alkali, chloroform as the solvent and 5c as the catalyst at room temperature for 24 h.