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原发全面强直阵挛癫痫功能连接密度图研究
  • ISSN号:1006-9011
  • 期刊名称:《医学影像学杂志》
  • 时间:0
  • 分类:R749.94[医药卫生—神经病学与精神病学;医药卫生—临床医学]
  • 作者机构:[1]北京大学精神卫生研究所,卫生部精神卫生学重点实验室(北京大学),北京100191, [2]北京师范大学认知神经科学与学习国家重点实验,脑与认知科学研究院,北京100875
  • 相关基金:国家自然科学基金(30970802,81000593,81020108022,81071109),“十一五”国家科技支撑计划资助(2007BA117B03)
中文摘要:

目的:探讨注意缺陷多动障碍(ADHD)儿童被动和主动内隐视觉空间注意特点。方法:选取符合美国精神障碍诊断与统计手册第4版(DSM一Ⅳ)ADHD诊断标准的儿童25例,以及性别、年龄与之匹配的正常儿童18名。分别测试反映被动内隐视觉空间注意的pop—out视觉搜索任务及反映主动内隐视觉空间注意的线索一目标视觉搜索任务,比较两组反应时(RT)、正确率和个体内反应时标准差(ISD)。结果:Pop—out视觉搜索任务中,ADHD儿童[(637.4±132.0)msVS.(626.3±125.0)ms]和正常儿童[(635.5±131.1)msVS.(626.6±138.5)ms]对左视野目标反应时均长于右视野(均P〈0.05),但是两组之间反应时、总体正确率差异无统计学意义(均P〉0.05);正常儿童左视野正确率低于右视野[(92.3±9.4)%VS.(94.5±8.1)%,P〈0.01],而ADHD儿童左右视野正确率差异无统计学意义[(91.9±7.4)%VS.(90.7±7.5)%,P〉0.05,ADHD儿童IsD大于正常儿童【(185.4±48.0)msVS.(137.5±36.7)ms,P〈0.01]。线索一目标任务中,ADHD儿童和正常儿童对左视野的目标反应时均长于右视野IADHD组,(641.1±94.2)msVS.(629.1±83.1)ms;正常对照组,(626.3±128.6)msVS.(614.9±133.1)ms;均P〈0.05],且线索提示有效目标反应时短于线索提示无效[ADHD组,(627.6±89.4)msvs.(654.3±84.6)ms,P〈0.01;正常对照组,(615.4±132.5)msVS.(627.3±127.5)ms,P〈0.01];两组之间反应时和正确率差异无统计学意义,ADHD儿童ISD大于正常儿童[(200.1±46.8)msvs.(147.8±32.8)ms,P=0.05]。结论:与正常儿童相比,ADHD儿童无论是被动还是主动内隐视觉空间注意,其注意力状态均不稳定,波动性增大,注意力维持困难。

英文摘要:

Objective: To investigate the characteristic of bottom-up and top-down visual spatial attention in children with attention-deficit/hyperactivity disorder ( ADHD). Methods: Twenty-five drug-naive children with ADHD meeting the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and 18 age-and gender-matched normal children were recruited. They performed the pop-out and cue-target visual search task which were designed to test the covert reflexive attention and covert effortful attention respectively. The differences in reaction times (RT), accuracy rates and intra-individual standard deviation of RT (ISD) between the two groups were compared. Results: In pop-out visual search task, children with ADHD [ (637.4 ± 132. 0) ms vs. (626. 3 ± 125.0) ms] and normal controls [(635.5 ± 131.1) ms vs. (626. 6 ±138.5) ms] both had longer RT to left visual field (RVF) target than to right visual field (LVF) target ( Ps 〈 0.05), while no differences were found between the two groups. The normal children had lower accuracy rates to LVF target than RVF target [ ( 92. 3± 9. 4) % vs. ( 94. 5± 8. 1)%, P 〈 0. 01 ], while no differences were found between LVF target and RVF target in children with ADHD [ (91.9 ± 7.4) % vs. ( 90.7 ± 7.5) %, P 〉 0. 05 ]. The ISD was higher in children with ADHD than in normal children [ ( 185.4±48.0) ms vs. ( 137.5± 36. 7) ms, P = 0. 001]. In cue-target visual search task, both children with ADHD and normal children had shorter RT to RVF target than LVF target [ ADHD group, (629. 1 ±83.1) ms vs. (641.1 ±94.2) ms, P 〈0. 05] ; normal control group, [(614.9±133.1) ms vs. (626.3 ± 128. 6) ms, P 〈 0. 05] and shorter RT to validly cued target than invalidly cued target[ ADHD group, (627. 6 ± 89.4) ms vs. (654. 3±84. 6) ms, P 〈0. 01; normal control group, (615.4 ± 132. 5) ms vs. (627.3 ±127.5) ms, P 〈 0. 01]. There were no difference

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期刊信息
  • 《医学影像学杂志》
  • 中国科技核心期刊
  • 主管单位:山东省卫生厅
  • 主办单位:山东省医学影像学研究会 山东省医学影像学研究所
  • 主编:赵斌
  • 地址:山东省济南市经四纬九路37号
  • 邮编:250021
  • 邮箱:xyxxzz@126.com
  • 电话:0531-87920996 87031478
  • 国际标准刊号:ISSN:1006-9011
  • 国内统一刊号:ISSN:37-1426/R
  • 邮发代号:24-134
  • 获奖情况:
  • 2007年山东省优秀科技期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,波兰哥白尼索引,美国剑桥科学文摘,英国科学文摘数据库,中国中国科技核心期刊
  • 被引量:28228