中文摘要：

目的：研究葛根丹参（乙酸乙酯部位）组方配伍（1：1）对高脂血症大鼠脂质代谢的影响．方法：采用高脂乳液灌胃法复制大鼠高脂血症动物模型，观察葛根丹参组方配伍后对大鼠血脂水平的影响．结果：葛根丹参（乙酸乙酯部位）组方配伍后能显著降低高脂血症大鼠血清中TC、TG、LDL．C和MDA的含量，纠正TG／HDL．C、LDL．C／HDL．C比值，增加HDL-C的含量，提高SOD的活力．结论：葛根丹参组方配伍（1：1）具有一定的调节脂质代谢、抗脂质过氧化的作用，该作用可能是葛根丹参配伍防治动脉粥样硬化的药理学基础．

英文摘要：

Objective： To study the effects of ethyl acetate extracts from Gegen-Danshen （1：1） prescription on the lipid metabolism in hyperlipidemia rats. Methods： The hyperlipidemia rats are induced by high fat emulsion via oral administration, and then the effect of Gegen-Danshen prescription on the levels of blood lipid in hyperlipidemia rats is observed. Results： The ethyl acetate extracts from Gegen-Danshen （1 ：l） prescription could significantly reduce the levels of serum total cholesterol （TC）, triglycerides （TG）, low-density lipoprotein cholesterol （LDL-C）, and malondialdehyde （MDA）. And the ratios of TG/HDL-C and LDL-C/HDL-C are clearly corrected via Gegen-Danshen prescription treated. Furthermore, oral administration of Gegen-Danshen prescription also enhances the levels of serum high-density lipoprotein cholesterol （LDL-C） and the activity of serum superoxide dismutase （SOD）. Conclusion： The results of the study suggests that Gegen-Danshen （l：l） prescription could not only ameliorate the lipid metabolism, but also act against lipid peroxidation. And these effects of Gegen-Danshen （1：1） prescription provide basic pharmacological information and might contribute to the treatment of atherosclerosis.