中文摘要：

MicroRNA（miRNA）是一种非编码的小分子RNA,在基因的表达调控过程中起着非常重要的作用。近几年的研究表明,miRNA的表达与人类脂肪组织分布有关,它不但降低脂代谢相关基因的表达,而且抑制脂代谢相关通路（如Wnt通路）,并在脂肪细胞的分化以及脂代谢的调节中发挥重要作用,其水平的变化可导致相应的脂质代谢紊乱及肥胖症等疾病的产生,从而可能成为新的药物设计和治疗靶点。

英文摘要：

MicroRNAs（miRNAs） are small,non-coding regulatory RNAs,which play important roles in the regulation of gene expression.Recent studies indicate that the expression of miRNAs is closely related with the distribution of adipocyte tissues,which not only downregulates the gene expression of lipid metabolism but also inhibits the signal pathway of fat metabolism such as Wnt pathway,and contributes to the adipocyte differentiation or lipid metabolism.The change of miRNAs expression level could lead to lipid metabolism disorder and obesity.Therefore,miRNAs are emerging as novel therapeutic targets for obesity.