中文摘要：

目的探讨Toll样受体2（TLR2）mRNA和Toll样受体4（TLR4）mRNA在银屑病皮损中表达的变化。方法采用原位杂交技术检测银屑病皮损处和正常皮肤中TLR2 mRNA和TLR4m RNA的表达情况。结果寻常型银屑病皮损中TLR2 mRNA和TLR4 mRNA主要表达于表皮基底上层;正常皮肤则表达于表皮的基底层。统计学分析表明,TLR2 mRNA和TLR4 mRNA在正常皮肤和银屑病皮损处基底层和基底上层的表达差异均有统计学意义（P〈0.05）,且TLR2 mRNA和TLR4 mRNA在银屑病皮损中的表达均高于正常皮肤组织（P〈0.05）。结论 TLR2和TLR4可能在银屑病的发生与发展过程中发挥重要的作用。

英文摘要：

Objective To detect the expression of toll-like receptor 2（TLR2） mRNA and toll-like receptor 4（TLR4） mRNA in psoriatic skin lesions.Methods By using in situ hybridization,TLR2 mRNA and TLR4 mRNA expression levels were detected in psoriatic lesional and normal skin tissues.Results TLR2 mRNA and TLR4 mRNA were highly expressed in the suprabasal layer of psoriatic lesions,while in normal epidermis TLR2 mRNA and TLR4 mRNA were expressed in the basal layer of epidermis.There was a significant difference between psoriatic lesion and the normal epiderm（P0.05）,and TLR2 mRNA and TLR4 mRNA expressions were higher in psoriatic lesional epidermis than in the normal epidermis.Conclusion TLR2 and TLR4 may play a crucial role in the pathogenesis and development of psoriasis.