中文摘要：

咪唑立宾作为一种抗代谢类免疫抑制剂,通常采用1～3 mg/（kg·d）的剂量。但随着肾移植技术的不断发展,有研究提示该剂量下咪唑立宾的抗排斥效应弱于同类药物吗替麦考酚酯。近年来日本学者开展了一系列研究,对肾移植受者给予5～6 mg/（kg·d）的咪唑立宾,结果显示其免疫抑制效应与吗替麦考酚酯相当,安全性较好。本文重点对此进行综述。

英文摘要：

As an effective oral immunosuppressant, mizoribine is usually recommended for kidney transplantation at the dose of 1-3 mg/（kg·d）. However, as the development of kidney transplantation technology, some researches suggest that this dosage displays an inferior anti-rejection effect when compared with mycophenolate mofetil. Recently, high-dose [5-6 mg/（kg·d）] of mizoribine has been used for renal transplants in Japan and it has already achieved promising outcomes with satisfied anti-rejection effect and safety, which will be illustrated in this review.