中文摘要：

目的 建立一种适合于工业化生产的甘草中同步提取纯化甘草酸和甘草苷的工艺路线。方法 以甘草酸和甘草苷的提取率为综合指标，采用正交试验确定最佳提取条件；并以甘草酸和甘草苷的保留率和除杂率为指标，通过正交试验优选最佳超滤工艺参数。结果 最佳提取条件为0.75%氨水24倍，提取3次，每次60 min，在此条件下，甘草酸和甘草苷平均提取率分别为98.3%和72.3%；最佳超滤工艺参数：在无机陶瓷膜孔径为10 nm、压力0.12 MPa和温度25℃的条件下，甘草酸和甘草苷平均保留率分别为99.3%、98.9%，且平均除杂率为23.3%。结论 该实验采用的无机陶瓷膜超滤技术与氨水提取工艺的联合应用，实现了甘草酸和甘草苷的同步提取和纯化，且工艺生产成本低，安全性好，适合工业化应用。

英文摘要：

Objective To establish an extraction and purification process line synchronization suitable for industrial production of glycyrrhizin acid and liquiritin.Methods The extraction rates of glycyrrhizic acid and liquiritin were as indexes,orthogonal test was performed to determine the optimum conditions;The retention rate of glycyrrhizic acid and liquiritin and impurity removal rates were as indexes,the best ultrafiltration process parameters were optimized by orthogonal test.Results The optimum extraction conditions were as follows：0.75% ammonia water （24 times）,extracted for three times,each time under 60 min,average rates of glycyrrhizic acid and liquiritin were 98.3% and 72.3%;The best ultrafiltration process parameters：10 nm inorganic ceramic membrane,pressure of 0.12 MPa,temperature of 25℃.The average retention rates of glycyrrhizic acid and liquiritin were 99.3% and 98.9%,and an average removal rate of impurity was 23.3%.Conclusion The experiment adopted the joint application of inorganic ceramic membrane ultrafiltration technology and ammonia extraction process,and it has realized the glycyrrhizic acid and licorice glycosides extraction and purification of synchronization;The process has low production cost and good safety,and is suitable for industrial application.