中文摘要：

目的 研究聚乙二醇（PEG）的加入对肝素化聚己内酯/聚乙二醇（PCL/PEG）人工血管膜材料中肝素体外释放的影响。 方法 通过共混法和冷冻干燥技术制备不同PEG质量分数（0、5%、10%、15%）的肝素化PCL/PEG膜材料，并通过体外释放实验考察PEG的加入对肝素释放性能的影响。同时，通过X射线衍射、傅里叶红外光谱和差示扫描热分析仪探究PEG的加入对基体结构性能的影响。 结果 PEG的加入降低了肝素从基体释放的难度，提高了肝素第1天的平均释放速率和34 d内的累积释放率，且两者在一定程度上随着PEG质量分数的增加而增大。X射线衍射、傅里叶红外光谱和差示扫描热分析结果均表明，肝素的加入会使PCL膜的结晶度在一定程度上有所增大，但整体影响并不显著，且肝素的加入会促进PEG晶粒的生长，肝素和PEG在基体中呈现共域化分布。 结论 利用共混法和冷冻干燥技术制备了肝素化PCL/PEG膜材料，并可通过调控PEG的质量分数在一定程度上实现对肝素释放行为的控制，进而预测试样在一定程度上具有抗凝作用，该材料有望用作小口径人工血管膜材料。

英文摘要：

Objective To investigate the influence of polyethylene glycol （PEG） on heparin release of heparin-loaded polycaprolactone/polyethylene glycol （PCL/PEG） membranes used in artificial vascular peosthesis. Methods Heparin-loaded PCL/PEG membrane samples with different PEG mass contents of 0, 0.5%, 10% and 15% were prepared by blending method and freeze-drying technology. The influence of PEG on heparin release was experimental studied in vitro. The influence of PEG on the structural characteristics of the samples were investigated by X-ray diffraction, Fourier transform infrared spectrum and differential scanning calorimeter. Results The addition of PEG reduced the heparin release resistance. The results showed that the average release rate of heparin in the first day and the release amount for 34 d were improved. Both these parameters increased with the increase of PEG mass content. The X-ray diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry showed that the crystallinity of PCL membrane was slightly enhanced by the addition of heparin, but the overall effect was not significant. In addition, the addition of heparin could promote the crystalline grain growth of PEG, and a common distribution of heparin and PEG in the matrix was observed. Conclusions The heparin release control can be achieved by adjusting the PEG mass content in heparin-loading PCL/PEG membranes prepared by blending method and freeze-drying technology. The proposed samples may have anticoagulant effect, which can be expected to be used as small-diameter artificial vascular prosthesis material.