中文摘要：

组织工程复合物用于骨缺损治疗是目前研究的热点,力学载荷对组织工程复合物在体成骨具有重要意义,相关研究越来越受到研究者们的关注.在组织工程研究领域,建立标准化的动物模型是进行实验研究的基础,用于探索不同力学载荷环境对骨缺损原位修复的影响及其作用机制.综述了力学载荷干预骨缺损修复实验模型的建立方法,对常用的动物选择、缺损制备、固定方法及载荷加载方式进行总结,为相关研究提供实验模型选择方面的参考.

英文摘要：

Tissue engineering composites for bone defect treatment is currently a hot spot of the research field. Mechanical loading on tissue engineering composites is important to bone formation and related research has attracted more and more attention. In the field of tissue engineering research, the establishment of a standardized animal model is the basis of experimental research for exploring the effects of different mechanical loading on in situ repair of bone defect and its action mechanism. This paper reviews the approaches used to establish experimental model of bone defect under mechanical loading such as animal selection, defect preparation, fixation and loading mode in order to provide a reference for related research.