中文摘要：

合成了N,N＇-双（4-氯苄基）-1,2-丙二胺铜（Ⅱ）配合物[CuCl（C17H20Cl2N2）2].（NH4）.Cl2,通过元素分析和IR光谱对其进行了表征,并通过X射线单晶衍射确定了其晶体结构.晶体结构分析表明,该晶体属于三斜晶系,P1空间群,晶胞参数a=1.35222（16）nm,b=1.37899（17）nm,c=1.39806（19）nm;α=60.954（1）°,β=87.502（2）°,γ=65.970（1）°,V=2.0424（4）nm3,Dc=1.357 g/cm3,Z=2,F（000）=862,R1=0.0925,wR2=0.2668[I〉2σ（I）],S=1.001.配合物的金属中心与来自2个配体的4个氮原子和1个末端氯原子配位,形成了轻微扭曲的四方锥几何构型,扭曲指数τ=0.04（1）.抗菌实验结果显示,配合物对大肠杆菌、枯草杆菌和金色葡萄球菌均表现出良好的抑菌作用.采用荧光光谱研究了不同温度下配合物与牛血清白蛋白（BSA）的相互作用,结果表明,配合物对BSA的荧光猝灭属于静态猝灭.计算了不同温度下配合物与BSA间的结合常数（Ka）、结合位点（n≈1）及相关热力学参数（ΔH〉0,ΔS〉0,ΔG〈0）,结果表明,二者主要靠疏水作用力结合.依据Fster的非辐射能量转移理论,求得给体（BSA）与受体（配合物）间的距离r=2.56 nm,说明配合物与BSA之间可能发生了非辐射能量转移.

英文摘要：

A new copper（Ⅱ） complex with ligand N,N′-bis（4-chlorobenzyl）propane-1,2-diamine,[CuCl（C17H20Cl2N2）2]·NH4·Cl2,has been synthesized and characterized by elemental analysis,IR spectra and single crystal X-ray diffraction methods.The crystal of copper（Ⅱ） complex belongs to triclinic system with space group P1,a=1.35222（16）nm,b=1.37899（17）nm,c=1.39806（19）nm;α=60.954（1）°,β=87.502（2）°,γ=65.970（1）°,V=2.0424（4） nm3,Dc=1.357 g/cm3,Z=2,F（000）=862,R1=0.0925,wR2=0.2668[I2σ（I）],S=1.001.The copper（Ⅱ） atom of the metal center in complex is five-coordinated by four N atoms from two ligand molecules and a terminal Cl atom,and the coordination polyhedron around the Cu atom can be described as a slightly distorted square pyramid-geometry with a distortion index τ value of 0.04（1）.The complex exhibited good antibacterial properties and the interaction of complex and bovine serum albumin（BSA） was investigated by fluorescence spectroscopy at different temperatures.The results indicated that the complex caused the fluorescence quenching of BSA through a static quenching procedure.The binding constants（Ka）,the number of binding sites（n≈1）,and corresponding thermodynamic parameters enthalpy change（ΔH0）,entropy change（ΔS0）,Gibbs free energy change（ΔG0）,between complex and BSA at different temperatures were calculated.The primary binding pattern between complex and BSA was interpreted as hydrophobic interaction.The binding average distance r between the donor（BSA） and acceptor（complex） was obtained to be 2.56 nm based on the Fster＇s theory,which indicates the energy transfer can occur from BSA to complex with high probability.