中文摘要：

Q热是由贝氏柯克斯体引起的呈世界性分布的一种人兽共患疾病。目前,世界反恐组织已将该病病原体列为生物战剂之一。早期应用抗生素对Q热有疗效,而慢性Q热治疗周期长、易复发,死亡率高。贝氏柯克斯体能以气溶胶的形式传播,一旦流行将难以控制,因此对人类危害极大。为进一步研究该病的致病机制、及时有效的诊断手段及其疫苗的开发提供参考依据,本文就贝氏柯克斯体的分子生物学研究进展作简要概述。

英文摘要：

Q fever caused by Coxiella burnetii is a zoonoses with worldwide distribution. At present, the global anti- terrorism organization has included the pathogen as a biological warfare agent. Although antibiotics is effective for acute patient, the treatment of chronic Q fever usually needs a long period with high relapse rate and ease-fatality.Otherwise, Q fever is difficult to control once epidemic occurs and lead to consequent great harm to mankind because the pathogen could be spread by aerosol. To provide reference for the further study of pathogcnesis, providing timely and effective diagnostic techniques and development of Coxiella burnetii vaccine, this paper summaries the progress on the molecular biology research of Coxiella burnetii.