中文摘要：

目的探讨系统性红斑狼疮（SLE）患者器官及系统受累与免疫学指标的相互关系。方法采用回顾性研究并用调查表的形式收集2047例SLE患者的临床资料,并对器官及系统受累与免疫学指标之间的联系进行相关性分析。结果关节受累与脱发、雷诺现象、抗RNP抗体、血清IgG升高相关;皮肤受累与脱发相关,肾脏受累与胸膜炎、腹膜炎、抗dsDNA抗体、抗C1q抗体相关;中枢神经系统受累与贫血相关;肺脏受累与口腔溃疡、心包炎、胸膜炎相关。结论 SLE患者器官/系统受累与免疫学特征及部分临床表现相关。

英文摘要：

Objective To explore the association of organs and system involvements with immunological features of Chinese SLE patients. Methods We had retrospectively reviewed the hospital charts of 2,047 SLE patients by questionnaire. The association of organs and system involvements with immunological feature was analyzed. Results Articular involvement was significantly correlated with alopecia,Raynaud＇s phenomenon,anti-RNP antibodies and elevated immune globulin G. Cutaneous involvement was significantly associated with alopecia. Renal involvement was significantly associated with pleurisy,peritonitis,anti-dsDNA antibodies,anti-C1q antibodies. Central nervous system involvement was associated with anemia. Lung involvement was associated with oral ulcers,pericarditis, pleuritis. Conclusion Organs and system involvements are correlated with some clinical and immunological profiles of SLE.