首次利用手性哌啶酰胺类和叔丁基亚磺酰胺类路易斯碱催化三氯氢硅对Ⅳ.酰基烯胺的不对称还原反应,以优良的收率(〉90%)和中等的对映选择性(2%ee-36%ee)获得了相应的Ⅳ-酰基手性胺产物。
Chiral piperidine-2-carboxamides and t-butyl sulfinamides have been for the first time used as Lewis base catalysts for the asymmetric reduction of N-acyl enamines by trichlorosilane, which proved to be effective for a broad range of substrates, affording the corresponding chiral N-aeyl amine products in high yields( 〉 90% ) and moderate enantioselectivities( 2%ee~36% ee).