中文摘要：

目的 探讨晚期胃肠道肿瘤患者肠道菌群紊乱及益生菌干预作用的临床效果。方法 选择2015年6月-2016年6月期间收治的50例晚期胃肠道肿瘤患者作为研究组,分别在益生菌干预前后检测粪便中大肠杆菌、双歧杆菌、乳酸杆菌、肠球菌、酵母菌、葡萄球菌、消化链球菌数量,并与同期30例健康对照组作比较。结果 益生菌干预前研究组双歧杆菌、乳酸杆菌及酵母菌数量明显少于对照组（P〈0.05）,大肠杆菌、葡萄球菌、肠球菌及消化链球菌数量明显多于对照组（P〈0.05）。经益生菌干预后研究组双歧杆菌、乳酸杆菌及酵母菌数量明显较干预前增加（P〈0.05）,大肠杆菌、葡萄球菌、肠球菌及消化链球菌数量明显较干预前减少（P〈0.05）。临床总有效率为92.0%。结论 晚期胃肠道肿瘤患者伴有明显的肠道菌群紊乱,经益生菌干预能够有效纠正道菌群紊乱。

英文摘要：

Objective To research of intestinal flora disturbance and probiotics intervention in patients with advanced gastrointestinal cancer. Methods 50 cases patients with advanced gastrointestinal cancer from June 2015 to June 2016 were collected, as research group, and escherichia coli, bacillus coli, lactic acid bacteria, lactic acid bacteria, yeast, staphylococcus and peptostreptococcus were detected before and after the intervention of probiotics, and were compared with 30 cases of healthy control group duringthe same period. Results Before probiotic intervention,the bacillus bifidus, lactic acid bacteria and yeast in the research group were significantly less than those in the control group （P〈0.05）, and escherichia colii, staphylococcus, streptococcus and peptostreptococcus were significantly more than those in the control group（P〈0.05）. After probiotic intervention,the bacillus bifidus,lactic acid bacteria and yeast in the research group were significantly increased compared with before intervention （P〈0.05）, and escherichia colii, staphylococcus, streptococcus and peptostreptococcus were significantly reduced compared with before intervention（P〈0.05）. The clinical total effective rate was 92.0%. Conclusion Patients with advanced gastrointestinal cancer have obvious intestinal flora disorder, and probiotics intervention can rectify the disorder of intestinal flora effectively.