中文摘要：

目的探讨自体外周血造血干细胞移植（APBSCT）治疗多发性骨髓瘤（MM）的疗效。方法该院自2006年12月至2011年10月,对18例MM患者,采用化疗联合粒细胞集落刺激因子（G-CSF）动员造血干细胞,以口服或静脉注射美法仑预处理后行APBSCT治疗,并评价其疗效。结果 17例患者移植成功,1例植入失败。移植后随访3～60个月,13例获得完全缓解（CR）,6例CR后复发,复发患者中1例经万珂治疗后再次获得CR。1例患者行2次移植达到非常好的部分缓解（VGPR）。结论 MM患者行APBSCT安全有效且耐受性好。移植后维持治疗对于延长无事件生存期（EFS）及总生存期（OS）具有重要意义。

英文摘要：

Objective To investigate the effect of autologous peripheral blood stem cell transplantation（APBSCT） in treating multiple myeloma（MM）.Methods 18 cases of MM in this hospital from December 2006 to October 2011 were given the chemotherapy combined with granulocyte colony stimulating factor（G-CSF） for mobilizing hematopoietic stem cells.APBSC was performed after the pretreatment of oral or intravenous melphalan.The effects were evaluated.Results 17 cases were succeeded in transplantation and 1 case failed.Follow up lasted for 3-60 months after transplantation.13 cases achieved complete remission（CR） and 6 cases relapsed after CR.Among the relapsed cases,1 case got CR again after bortezomib treatment.1 case got VGPR after second APBSCT.Conclusion APBSCT is a safe and efficient therapy and well tolerable for MM.Maintenance treatment after APBSCT has the important significance to prolong the event free survival（EFS） and overall survival（OS）.