欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
采用双乳化-凝胶法制备了单分散的海藻酸钙凝胶微球,并通过正交试验系统考察了海藻酸钠浓度、氯化钙浓度、表面活性剂浓度、搅拌速度和油水比对海藻酸钙凝胶微球粒径及形貌的影响。在优化的条件下,制备出了平均粒径为4μm、单分散和球形度好的海藻酸钙凝胶微球。包埋模型药物牛血清白蛋白(BSA)的过程中,以去离子水作为洗涤液洗涤海藻酸钙微球时,BSA的包封率仅为13%左右;当水洗液的pH值为3.2时,BSA的包封率提高到66%左右,载药率可达16%,这是海藻酸钙pH值响应溶胀和BSA与海藻酸盐之间静电作用的结果。微球中BSA的体外释放曲线表明,该系统具有在模拟胃液中释药速率慢、释药量低、模拟肠液中释药迅速的特性。因此,双乳化-凝胶法制备海藻酸钙微球有望成为制备蛋白类药物控释制剂的一种新方法,以达到靶向快速给药的目的。
英文摘要：
采用双乳化-凝胶法制备了单分散的海藻酸钙凝胶微球,并通过正交试验系统考察了海藻酸钠浓度、氯化钙浓度、表面活性剂浓度、搅拌速度和油水比对海藻酸钙凝胶微球粒径及形貌的影响。在优化的条件下,制备出了平均粒径为4μm、单分散和球形度好的海藻酸钙凝胶微球。包埋模型药物牛血清白蛋白(BSA)的过程中,以去离子水作为洗涤液洗涤海藻酸钙微球时,BSA的包封率仅为13%左右;当水洗液的pH值为3.2时,BSA的包封率提高到66%左右,载药率可达16%,这是海藻酸钙pH值响应溶胀和BSA与海藻酸盐之间静电作用的结果。微球中BSA的体外释放曲线表明,该系统具有在模拟胃液中释药速率慢、释药量低、模拟肠液中释药迅速的特性。因此,双乳化-凝胶法制备海藻酸钙微球有望成为制备蛋白类药物控释制剂的一种新方法,以达到靶向快速给药的目的。
同期刊论文项目
同项目期刊论文
Study on conductivity property and microstructure of TritonX-100/alkanol/n-heptane/water microemulsi
The Synthesis of Mesoporous TiO2/SiO2/Fe2O3 Hybrid Particles, Containing Micelle- Induced Macropores
Magnetic titania-silica composite-Polypyrrole core-shell spheres and their high sensitivity toward h
Antifouling enhancement of poly(vinylidene fluoride) microfiltration membrane by adding Mg(OH)(2) na
Prediction of the effects of preparation conditions on pervaporation performances of polydimethylsil
Effect of formamide additive on the structure and gas permeation performance of polyethermide membra
Magnetic TiO2-SiO2 hybrid hollow spheres with TiO2 nanofibers on the surface and their formation mec
Pore size and surface area control of MgO nanostructures using a surfactant-templated hydrothermal p
Effects of Additives on Water Solubilization Capacity and Intermicellar Interaction in Heptane/Hexan
Experimental and CFD Studies on the Performance of Microfiltration Enhanced by a Turbulence Promoter
Hydroxide exchange composite membrane based on soluble quaternized polyetherimide for potential appl
Effects of surfactant concentration on alkyl chain arrangements in dry and swollen organic montmoril
Further separation of HFC-23 and HCFC-22 by coupling multi-stage PDMS membrane unit to cryogenic dis
Electrodeposition of high-capacitance 3D CoS/graphene nanosheets on nickel foam for high-performance
Preparation of hollow submicrospheres with ordered porous SiO2 shell and multiple AuPt nanoalloy cor
A novel membrane distillation response technology for nucleation detection, metastable zone width me
Calculation on phase diagrams of polyetherimide/N,N-dimethylacetamide/H2O-BuOH casting system and th
Effects of hydrophobicity of diffusion layer on the electroreduction of biomass derivatives in polym
Enhancement of hydroxide conductivity by the di-quaternization strategy for poly(ether ether ketone)
Influences of Van Der Waals Volume of Substitute Groups on CO2 Permselectivity of Polyimide-A Molecu
Properties and morphology of Nafion/polytetrafluoroethylene composite membrane fabricated by a solut
Fractal slice model analysis for effective thermal conductivity and temperature distribution of poro
Optimization of ethyl acetate process conditions for sodium bisulfate fluidized catalytic distillati
Formation Mechanism of Zinc Oxalate Particles in the Internal Aqueous Droplets of Emulsion Liquid Me
Artificial neural network model for turbulence promoter-assisted crossflow microfiltration of partic
Cleaner recovery of tetrafluoroethylene by coupling residue-recycled polyimide membrane unit to dist
Research Progress and Model Development of Crystal Layer Growth and Impurity Distribution in Layer M
Falling film melt crystallization (III): Model development, separation effect compared to static mel
Imidazolium-functionalized poly(ether ether ketone) as membrane and electrode ionomer for low-temper
Fabrication of polyetherimide microporous membrane using supercritical CO2 technology and its applic
Improvement of bilirubin adsorption capacity of cellulose acetate/polyethyleneimine membrane using s
Improving CO2 separation performance of the polyethylene glycol (PEG)/polytrifluoropropylsiloxane (P
Hybrid UV photodetector with high photo-to-dark current ratio based on ordered TiO2 nanorod arrays a
Progress in the application of fractal porous media theory to property analysis and process simulati
Boiler system design based on stochastic programming under uncertain steam demand and equipment fail
Magnetic C-C@Fe3O4 double-shelled hollow microspheres via aerosol-based Fe3O4@C-SiO2 core-shell part
Activation of the solid silica layer of aerosol-based C/SiO2particles for preparation of various fun
Electrospun nanofiber enhanced imidazolium-functionalized polysulfone composite anion exchange membr
Shape-controlled synthesis of magnetic iron oxide@SiO2-Au@C particles with core-shell nanostructures
Fe3O4 doped double-shelled hollow carbon spheres with hierarchical pore network for durable high-per
Effect of hydrogen bonding on self-diffusion in methanol/water liquid mixtures: A molecular dynamics
A Methanesulfonic Acid/Sulfuric Acid-Based Route for Easily-Controllable Chloromethylation of Poly(e
Modification of Hydrophilic Channels in Nafion Membranes by DMBA: Mechanism and Effects on Proton Co
Optimization of ultrafiltration membrane fabrication using backpropagation neural network and geneti
A comparison of cake properties in traditional and turbulence promoter assisted microfiltration of p
Controlling fuel crossover and hydration in ultra-thin proton exchange membrane-based fuel cells usi
Molecular Dynamics Simulation of Reverse-Osmotic Salt Rejection and Water Transport through Double-W
Parameters optimisation of isopropanol purification by hybrid distillation-vapour permeation process
Particles deposition on microfiltration permeable boundary: Modeling and simulation with two-ways co
The addition of a pH-sensitive gel improves microemulsion stability for the targeted removal of colo
期刊信息
位置：