中文摘要：

目的：探讨e NOS基因与＂阴虚体质-亚健康-缺血性卒中＂演变轴的关系。方法：研究共3个对照组,即：阴虚体质组、阴虚体质亚健康组、阴虚体质缺血性卒中组,每组100例。对300例研究对象进行基因检测。结果：携带AA基因型的个体缺血性脑卒中的发病风险增加,缺血性卒中组与阴虚体质组携带AA基因型频数比较差异显著（P〈0.05）,缺血性卒中组与阴虚体质亚健康组携带AA基因型频数比较差异无统计学意义（P〉0.05）,表明携带AA基因型的个体,从阴虚体质-亚健康-缺血性脑卒中是递增过程。结论：e NOS基因-922G/A变异与缺血性脑卒中显著相关。为研究阴虚体质-亚健康-缺血性卒中＂演变轴提供基因基础。

英文摘要：

Objective： To explore the relationship between e NOS gene and evolution axis from yin deficiency constitution to subhealth to ischemic stroke. Methods： The research had 3 control groups： the yin deficiency constitution group,the yin deficiency constitution sub-health group,and the yin deficiency constitution ischemic stroke group,with 100 cases in each group. The genes of 300 research objects were tested. Results： The onset risk of ischemic stroke of individuals with AA genotype increased; And the difference in frequency with AA genotype between the yin deficiency constitution ischemic stroke group and the yin deficiency constitution group had significance（ P〈0. 05）,while the difference in frequency with AA genotype between the yin deficiency constitution ischemic stroke group and the yin deficiency constitution sub-health group had no significance（ P〉0. 05）. This shows that the process from yin deficiency constitution to sub-health to ischemic stroke of an individual with AA genotype is incremental. Conclusion： ENOS gene-922-g / A variant were significantly associated with ischemic stroke. This provides genetic basis for the study of ＂ Yin deficiency constitution to sub-health to ischemic stroke evolution axis.