中文摘要：

Epithelialmesenchymal 转变(EMT ) 是在心肌的梗塞(MI ) 以后的心脏的纤维变性的重要机制。然而，它仍然保持不清楚是否 Snail1， EMT 的一个重要管理者，涉及心脏的纤维变性。在这研究，我们在老鼠探索了 Snail1 和心脏的纤维变性 markerperiostinafter MI 的表示模式然后在老鼠在 MI 以后调查了在 Snail1 和 periostin 之间的合作表示。我们的结果证明 Snail1 和 periostin 的 mRNA 和蛋白质层次显著地在梗塞区域被增加。Snail1 表示模式看起来在在 MI 以后的 14 天以内寓言。另外在 MI 以后，所有 Snail1 积极的房间能表示 periostin。这些结果显示 Snail1 主要在梗塞区域被激活并且涉及 de novo 在在老鼠的 MI 以后的心脏的纤维变性。因此，它是在为在 MI 以后的室的改变的药干预的发展的一个潜在的分子的目标。

英文摘要：

Epithelial- mesenchymal transition （EMT） is an important mechanism of cardiac fibrosis after myocardial infarction （MI）. However, it remains unclear whether Snail1, an important regulator of EMT, is involved in cardiac fibrosis. In this study, we explored the expression patterns of Snail1 and a cardiac fibrosis marker-- periostin--afler MI in mice and then investigated the co- expression between Snail1 and periostin after MI in mice. Our results showed that the mRNA and protein levels of Snaril1 and perioslin were significantly increased in the infarct area. The Snail1 expression pattern appeared to be parabolic within 14 days after MI. In addition, after MI, all Snail1- positive cells were able to express periostin. These results indi- cate that Snail1 is mainly activated in the infarct area and is involved in de novo cardiac fibrosis after MI in mice. Thus, it is a potential molecular target in the development of drug interventions for ventricular remodeling after MI.