中文摘要：

目的：观察中医复方对狼疮性肾炎患者高迁移率族蛋白1（HMGB1）、白细胞介素-10（IL-10）和转化细胞生长因子-β1（TGF-β1）的改变作用。方法：选取本院自2011年4月～2013年4月间收治的狼疮性肾炎患者124例，分为观察组（60例）和对照组（64例）；观察组给予中医复方治疗，对照组给予激素治疗。比较2组患者临床疗效和HMGB1、IL-10和TGF-β1检测指标的改变情况。结果：观察组总有效率为91．7％，对照组为81．3％，2组比较，差异有显著性意义（P〈0．05）。2组HMGB1、1IL-10、TGF-β1治疗前后组内比较，差异均有显著性意义（P〈0．05）。2组治疗后HMGB1、TGF-β1比较，差异也有显著性意义（P〈0．05）。结论：中医复方治疗狼疮性肾炎患者有较好的临床疗效，且能改善患者血清HMGB1、IL-10和TGF-β1水平，对病变的肾脏组织有着很好地修复作用。

英文摘要：

Objective： To observe the clinical efficacy of Chinese medicine compound on high mobility group protein B1 （HMGB1）, interleukin-10（IL-10） and transforming growth factor β1 （TGF-β1） in lupus nephritis patients. Methods. In our hospital from April of 2011 to April of 2013, 124 patients with lupus nephritis were divided into observation group（60 cases） and control group（64 cases）. The observation group was treated with traditional Chinese medicine compound orally, and the control group was given hormone orally. The clinical efficacy was compared in the two groups, and the changes of HMGB1, IL-10 and TGF-β1 were observed. Results： The total effective rate was 91.7% in the observation group and was 81.3% in the control group, and the difference was statistically significant （P 〈 0.05）. Serum indicators HMGB1, IL-10 and TGF-β1 were improved in the two groups after treatment （P 〈 0.05 compared with those before treatment）, and the improvement in the observation group was superior to that in the control group（P 〈 0.05）. Conclusion： Chinese medicine compound is effective for the treatment of lupus nephritis patients through improving serum HMGB1, IL-10 and TGF-β1 levels and promoting the repair of kidney tissue lesions.