中文摘要：

类法尼酯衍生物x受体（famesoidXreceptor,FXR）是配体激活的转录因子，为核受体超家族的主要成员。FXR在胆汁酸代谢、胆固醇代谢、脂代谢以及糖代谢中发挥重要作用。近期研究显示，FXR在代谢性疾病，如高糖血症和高脂血症，以及肠道炎症性疾病、肝再生，甚至肿瘤细胞的增殖和凋亡中发挥重要的调控作用。然而现阶段对于FXR的代谢调控作用在肿瘤发生、发展中的意义尚不明了，甚至存在争议。本文综述了FXR对代谢的调控作用，以及FXR对肿瘤细胞增殖的不同作用和相关机制研究的新进展。

英文摘要：

Farnesoid X receptor （FXR） is a ligand-activated transcriptional factor belonged to the superfamily of nuclear receptors. In the past decades, FXR has been found with important roles in the regulation of metabolic homeostasis of bile acids, cholesterol, lipids and carbohydrates. Recent studies further demonstrate the potential protective effect of FXR against metabolic diseases, such as hyperglycemia and hyperlipidemia, as well as inflammatory bowel diseases （IBD）. In addition, FXR plays an essential role in liver regeneration, tumor cell proliferation and apoptosis. However, the role of FXR in the development of tumor is still obscure and even with discrepancy. This article reviews the function of FXR in metabolic regulation and recent progress in basic, clinical and pharmacological researches related to tumor cell proliferation involving FXR.