分别在微波辐射和常规加热条件下,通过2-氨基-5-(1-苯基-3-甲基-5-氯吡唑-4-基)-1,3,4-噻二唑(1)与(未)取代苯甲酰氯(2a~2j)反应,合成了一系列未见文献报道的2-(未)取代苯甲酰胺基-5-(1-苯基-3-甲基-5-氯吡唑-4-基)-1,3,4-噻二哗衍生物(3a~3j).标题化合物的结构经元素分析,IR,^1HNMR确证.
A series of novel 2-(un)substituted benzamido-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)- 1,3,4-thiadiazole derivatives (3a--3j) have been synthesized by the reaction of 2-amino-5-(1-phenyl-3- methyl-5-chloropyrazol-4-yl)-1,3,4-thiadiazole (1) with (un)substituted benzoylchlorides (2a-2j) under a microwave radiation condition and an ordinary heating condition. The structures of these compounds were confirmed by elemental analysis, IR and ^1H NMR spectra.