中文摘要：

雌激素受体（estrogen receptor,ER）是诊断和治疗乳腺癌的分子标志和靶点.雌激素受体包括ER-α和ER-β,其中ER-α有ER-α66、ER-α46和ER-α36三种亚型.ER-α36作为新型雌激素受体,参与膜起始的雌激素信号或非基因组雌激素信号转导,在肿瘤细胞的增殖、分化、侵袭和转移等过程中发挥作用.胃癌、子宫内膜腺癌、前列腺癌、尤其是乳腺癌的发生发展与ER-α36密切相关.本文介绍了ER-α36的结构域特点,ER-α36介导的信号通路及ER-α36在乳腺癌治疗中的作用研究进展.

英文摘要：

Estrogen receptor（ ER） expression is an important prognostic and predictive factor in breast cancer. Estrogen receptors include ER-α and ER-β. There are three subtypes in ER-α,including ER-α66,ER-α46 and ER-α36. ER-α36,which is a novel isoform of human estrogen receptor,mediating non-genomic or membrane-initiated signaling pathway. ER-α36 plays a role in tumor cell proliferation,differentiation, invasion and metastasis. ER-α36 is closely related to gastric cancer, endometrial adenocarcinoma,prostate cancer,and especially the breast cancer occurrence and development. In this paper,we introduce the structural features,signaling pathways of ER-α36 and the role of ER-α36 in the treatment of breast cancer.