中文摘要：

目的通过应用丘脑底核（STN）的三维重建图获取更理想的穿刺角度，使电极通过核团的长度进一步延长。方法通过第三军医大学的中国数字化可视人体数据库中1例22岁女性模板重建了脑深部核团的3D图谱，并对其STN核团参数进行了测量。同时将回顾性分析的30例患者MRI图像信息同3D图谱的结果进行融合对比，获得MRI核团信息。结果3D图谱中STN的空间角度参数同30例患者影像资料数据间的差异小（差值的95％CI范围〈1），提示图谱的代表性好。在图谱上经过模拟电极测量得出推荐穿刺角度，即环角／侧角为：55°～57°／17°～19°，核团内部电极长度为（5．7±0．3）mm。结论3D图谱在脑深部核团的定位上具有较高的代表性，与个体的影像结果可以很好地融合；通过在图谱上进行测量可得出针道的适合穿刺角度组合，获得更长的核团内电极长度。

英文摘要：

Objective To measure the parameters of the specific electrode trajectory angles under the condition that the trajectory length in the nuclei could be as long as possible by using 3D reconstruction of subthalamic nucleus （STN）. Methods A 3D atlas of deep brain nuclei was built on the 3D reconstruction station, and the parameters of STN were measured. MR imaging of 30 Parkinson＇s disease （PD） patients was matched to the 3D atlas to acquire the average nucleus information. Results The STN spatial location parameters showed no significant statistical difference with imaging of these 30 patients （95% confidence interval of difference value〈1）, indicating that this 3D atlas enjoyed good representative value. After simulation, the optimal trajectory angles were achieved： the combination angles offing/slide： 55°-57°/17°-19°, which extended the trajectory within the nucleus to about （5.7±0.3） mm. Conclusion The 3D atlas shows high representative of locating deep brain nucleus and could be registrated well to particular patient＇s images. After simulation on the atlas, the optimal trajectory angles parameters can be obtained, which shows the specific operation of achieving longer length of electrode in nucleus.