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振腹对2型糖尿病大鼠血清游离脂肪酸和甘油三酯的影响
  • ISSN号:1674-1749
  • 期刊名称:环球中医药
  • 时间:2015.9
  • 页码:1070-1074
  • 分类:R244.1[医药卫生—针灸推拿学;医药卫生—中医临床基础;医药卫生—中医学]
  • 作者机构:[1]北京中医药大学针灸推拿学院,100029
  • 相关基金:国家自然科学基金(81202772)
  • 相关项目:振腹法振频对HPA轴的调节作用及其对II型糖尿病兔血糖的影响
中文摘要:

目的研究振腹对2型糖尿病大鼠血清游离脂肪酸及甘油三酯的影响。方法用高糖高脂联合小剂量链脲佐菌素建立2型糖尿病大鼠模型,最终模型组11只、低频治疗组9只、高频治疗组10只,设立12只正常大鼠为对照组,予振腹治疗6周,于治疗前后监测大鼠空腹血糖、游离脂肪酸、甘油三酯的水平。多组间差异比较采用单因素方差分析。结果治疗前,与对照组对比,其余各组大鼠空腹血糖、游离脂肪酸、甘油三酯的水平均升高(P〈0.05)。治疗后,与模型组对比,低频治疗组和高频治疗组大鼠空腹血糖、游离脂肪酸、甘油三酯的水平均降低(P〈0.05);低频治疗组和高频治疗组相比较,大鼠空腹血糖、游离脂肪酸、甘油三酯的水平无明显差异(P〉0.05)。结论振腹能降低2型糖尿病大鼠空腹血糖、游离脂肪酸、甘油三酯的水平,其机制可能为:(1)振腹通过调节肾上腺的分泌功能影响脂代谢;(2)增强腹部肌肉和胃肠道平滑肌运动,增加了组织对脂肪的氧化作用;(3)减少腹部及内脏脂肪异位堆积,提高腹部及内脏组织细胞胰岛素受体的敏感性。

英文摘要:

Objective To study the influences of the vibrating abdomen on serum free fatty acids and triglyceride in rats with type 2 diabetes mellitus. Methods The rat models were established by using high sugar fatty feed combined with injection of low dose of streptozotocin, finally the rats were divided into model group (n=11), low frequency treatment group (n=9) and the high frequency treatment group (n=10), and all the treatment were lasted for 6 weeks. Another 12 normal rats were chosen as the control group. Fasting blood-glucose (FBG), free futty acid(FFA) and triglyceride(TG) were tested in pre-therapy and post-treatment, and the results were analyzed by using one-way analysis of variance. Results Compared with the control group, the levels of FBG, FFA and TG in the rest another groups were increased significantly (P〈 0. 05). Compared with the model group, the levels of FBG, FFA and TG of rats in low frequency and high frequency treatment groups were decreased significantly (P〈0. 05). The differences in the levels of FBG, FFA and TG were not significant between low frequency treatment group and high frequency treatment group ( P〉0. 05 ) . Conclusions Vibrating abdomen could decrease the levels of FBG, FFA and TG of rats with type 2 diabetes mellitus, and the mechanism might be related with the following aspects:(1):Vibrating abdomen could influence the lipid metabolism by adjusting the secretion function of adrenal gland. (2) Vibrating abdomen could increase the lipid oxidation by strengthening the movement of abdominal muscles and gastrointestinal smooth muscles. ( 3 ) Vibrating abdomen could increase the sensitivity of insulin receptor in cells of abdomen and visceral by reducing the ectopic fat accu-mulation in abdomen and visceral.

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期刊信息
  • 《环球中医药》
  • 中国科技核心期刊
  • 主管单位:中华人民共和国卫生部
  • 主办单位:中华国际医学交流基金会
  • 主编:张伯礼
  • 地址:北京东城区东四西大街46号综合楼203
  • 邮编:100711
  • 邮箱:hqzhyy@163.com
  • 电话:010-65269860
  • 国际标准刊号:ISSN:1674-1749
  • 国内统一刊号:ISSN:11-5652/R
  • 邮发代号:80-726
  • 获奖情况:
  • 中国科技核心期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),美国剑桥科学文摘,中国中国科技核心期刊
  • 被引量:7690