目的探讨垂体后叶素联合酚妥拉明治疗支气管扩张咯血的疗效。方法将56例支气管扩张咯血患者按随机数字表法分为2组,治疗组(28例)联合应用垂体后叶素与酚妥拉明,对照组(28例)单纯应用垂体后叶素,比较2组的疗效及不良反应发生情况。结果治疗组总有效率为96.4%,对照组总有效率为82.0%,2组比较差异有统计学意义(P〈0.05),不良反应发生率治疗组为7.1%,对照组为46.4%,2组比较差异有统计学意义(P〈0.05)。结论垂体后叶素联合酚妥拉明治疗支气管扩张咯血的疗效显著,不良反应少。
Objective To investigate the efficacy of pituitrin combined with phentolamine in the treatment of hemoptysis caused by bronchiectasis.Methods Fifty-six patients with hemoptysis caused by bronchiectasis were randomly treated with pituitrin alone(control group,n=28)or in combination with phentolamine(treatment group,n=28).The efficacy and adverse reactions were compared between the two groups.Results Compared with control group,the combined treatment with pituitrin and phentolamine induced an increase in the total effective rate(96.4% vs82.0%,P〈0.05)and a decrease in the incidence of adverse reactions(7.1% vs 46.4%,P〈0.05).Conclusion The combination of pituitrin and phentolamine is an effective treatment with few side effects in patients with hemoptysis caused by bronchiectasis.