中文摘要：

窖蛋白1（caveolin-1）是胞膜窖（caveolae）上的标志性蛋白,能够识别多种信号分子,与肿瘤的侵袭转移及血管生成等过程密切相关。而caveolin-1在肿瘤血管生成中的作用尚未定论,目前认为caveolin-1在肿瘤及其血管生成中具有促进及抑制双重作用。随着研究的不断深入,caveolin-1很可能成为肿瘤的治疗靶点或早期诊断指标。本文就caveolin-1在肿瘤及其血管生成的作用进行综述。

英文摘要：

Caveolin- 1,the marker protein of caveolae,could recognize a variety of signal molecules and might be related to tumor metastasis and angiogenesis. The role of caveolin- 1 in tumor angiogenesis has not been ascertained yet. It has been shown that caveolin- 1 might play a dual function in tumor angiogenesis： either promoting or inhibiting. Caveolin- 1might act as an early diagnostic marker and therapeutic target in carcinoma. This article will review the effects of caveolin-1 on tumor invasion and angiogenesis and discuss the underlying mechanisms.